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Title: Synthesis, characterization and cytotoxicity of a palladium(II) complex of 3-[(2-hydroxybenzylidene)amino]-2-thioxoimidazolidin-4-one
Authors: Šmit, Biljana
Pavlovic, Radoslav
Radosavljević-Mihailović A.
Dosen, Dr. Anja
Ćurčić Milutinović, Milena
Šeklić, Dragana
Živanović, Marko
Issue Date: 2013
Abstract: The polydentate ligand 3-[(2-hydroxybenzylidene)amino]-2- thioxoimidazolidin-4-one was synthesized in the intermolecular cyclocondensation reaction of 2-hydroxybenzaldehyde thiosemicarbazone and ethyl chloroacetate. A novel palladium(II) complex was obtained from cis-[Pd(DMSO)2Cl 2] by nucleophilic substitution of both DMSO ligands with the iminic nitrogen and the thiolactamic sulfur from the ligand. The structures of the compounds were characterized based on their spectral data. The cytotoxic activities of the ligand and the palladium(II) complex were studied on the tumor cell lines: human colon carcinoma HCT-116 and SW-480 cells using the MTT viability test. The results showed that the investigated palladium(II) complex had a significantly greater cytotoxic effect compared to that of the ligand.
Type: article
DOI: 10.2298/JSC120725154S
ISSN: 0352-5139
SCOPUS: 2-s2.0-84874620305
Appears in Collections:Faculty of Science, Kragujevac
Institute for Information Technologies, Kragujevac

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