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https://scidar.kg.ac.rs/handle/123456789/10553| Title: | Transformation of primary myelofibrosis with 20q- in Philadelphia-positive acute lymphoblastic leukemia: Case report and review of literature |
| Authors: | Jurisic, Vladimir     Čolović N. Terzić D. Djordjevic V. Colovic, Mirjana |
| Issue Date: | 2012 |
| Abstract: | A 56-year-old male with chronic idiopathic myelofibrosis and cytogenetic finding of 20q- after a period of 10 months developed acute Philadelphia-positive lymphoblastic leukemia. Immunophenotyping of peripheral blood by flow cytometry showed HLA-DR, CD34, CD19, CD22, CD10, CD33, and CD11b positivity. Cytogenetic analysis revealed the presence of 20q- and Philadelphia chromosome t(9;22)(q34:q11) at the time of disease transformation to ALL. The JAK2V617F mutation was not found. This is a very rare case of simultaneous presence of two cytogenetics abnormalities and evolution of primary idiopathic myelofibrosis to Philadelphia-positive acute lymphoblastic leukemia. © 2012 Elsevier GmbH. |
| URI: | https://scidar.kg.ac.rs/handle/123456789/10553 |
| Type: | article |
| DOI: | 10.1016/j.prp.2012.04.007 |
| ISSN: | 0344-0338 |
| SCOPUS: | 2-s2.0-84863815856 |
| Appears in Collections: | Faculty of Medical Sciences, Kragujevac |
 | Page views(s)124 | Downloads(s)5 |
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|---|---|---|---|---|
| PaperMissing.pdf Restricted Access | 29.86 kB | Adobe PDF |  View/Open |
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