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Title: Transformation of primary myelofibrosis with 20q- in Philadelphia-positive acute lymphoblastic leukemia: Case report and review of literature
Authors: Jurisic, Vladimir
Čolović N.
Terzić D.
Djordjevic V.
Colovic, Mirjana
Issue Date: 2012
Abstract: A 56-year-old male with chronic idiopathic myelofibrosis and cytogenetic finding of 20q- after a period of 10 months developed acute Philadelphia-positive lymphoblastic leukemia. Immunophenotyping of peripheral blood by flow cytometry showed HLA-DR, CD34, CD19, CD22, CD10, CD33, and CD11b positivity. Cytogenetic analysis revealed the presence of 20q- and Philadelphia chromosome t(9;22)(q34:q11) at the time of disease transformation to ALL. The JAK2V617F mutation was not found. This is a very rare case of simultaneous presence of two cytogenetics abnormalities and evolution of primary idiopathic myelofibrosis to Philadelphia-positive acute lymphoblastic leukemia. © 2012 Elsevier GmbH.
Type: article
DOI: 10.1016/j.prp.2012.04.007
ISSN: 0344-0338
SCOPUS: 2-s2.0-84863815856
Appears in Collections:Faculty of Medical Sciences, Kragujevac

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