Please use this identifier to cite or link to this item: https://scidar.kg.ac.rs/handle/123456789/10682
Title: Protective effects of Alchemilla vulgaris L. extracts against cisplatin-induced toxicological alterations in rats
Authors: Jurić, Tatjana
Katanić Stanković, Jelena S.
Rosic, Gvozden
Selakovic, Dragica
Joksimovic, Jovana
Mišić D.
Stankovic, Vesna
Mihailovic, Vladimir
Journal: South African Journal of Botany
Issue Date: 1-Jan-2020
Abstract: © 2019 SAAB This study was designed to evaluate the possible effect of methanol extracts of aerial parts and roots of Alchemilla vulgaris L. (AVA and AVR, respectively) in preventing cisplatin-induced hepatorenal and testicular toxicity in rats. UHPLC/DAD/(−)HESI-MS/MS analysis was performed to determine the detailed phenolic profile of AVA and AVR. The male Wistar rats were orally treated with extracts at three different concentrations (50, 100, and 200 mg/kg b.w.) for 10 days and toxicity was induced by injection of single dose of cisplatin on the 5th day (7.5 mg/kg b.w.). Determination of serum biochemical markers of hepatorenal and testicular tissue injury, as well as oxidative-stress parameters in tissues and histopathological study, were performed. Treatments with AVA and AVR significantly attenuated the levels of serum parameters of liver, kidneys and testicles injury, tissue's morphology and parameters of oxidative stress caused by an application of the cisplatin. Chromatographic analysis showed the presence of more than 20 different phenolic compounds in extracts where ellagic acid, catechin, and catechin gallate were dominant components in both extracts. The obtained results indicate that A. vulgaris extracts may be used in preventing cisplatin-induced toxicity during chemotherapy as well as in the treatment of oxidative stress-related disorders.
URI: https://scidar.kg.ac.rs/handle/123456789/10682
Type: Article
DOI: 10.1016/j.sajb.2019.09.010
ISSN: 02546299
SCOPUS: 85074895646
Appears in Collections:Faculty of Medical Sciences, Kragujevac
Faculty of Science, Kragujevac
Institute for Information Technologies, Kragujevac
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