Please use this identifier to cite or link to this item: https://scidar.kg.ac.rs/handle/123456789/10828
Title: Synthesis of Racemic 2-(Aminomethyl)cyclopropane-1,1-dicarboxylic Acid as a New Constrained γ-Amino Dicarboxylic Acid Bypassing Alkyl 3-Aza-2-oxobicyclo[3.1.0]hexane-1-carboxylates
Authors: Mangelinckx S.
Kostic, Marina
Backx S.
Petrović, Biljana
De Kimpe N.
Issue Date: 2019
Abstract: © 2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim The first synthesis of racemic 2-(aminomethyl)cyclopropane-1,1-dicarboxylic acid was developed involving sequential iodocarbocyclization, azidation, saponification and reduction of dimethyl 2-allylmalonate. The developed synthetic pathway avoids reactions such as ring opening of the cyclopropane ring toward acyclic δ-amino carboxylic acid derivatives or lactamisation toward bicyclic methyl 3-aza-2-oxobicyclo[3.1.0]hexane-1-carboxylates which occur in alternative synthetic strategies.
URI: https://scidar.kg.ac.rs/handle/123456789/10828
Type: article
DOI: 10.1002/ejoc.201900542
ISSN: 1434-193X
SCOPUS: 2-s2.0-85067392777
Appears in Collections:Faculty of Science, Kragujevac
Institute for Information Technologies, Kragujevac

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