Please use this identifier to cite or link to this item:
Title: Phytochemical analysis and anti-inflammatory effects of Filipendula vulgaris Moench extracts
Authors: Katanić Stanković, Jelena S.
Pferschy-Wenzig, Eva-Maria
Mihailovic, Vladimir
Jurić, Tatjana
pan, sudip
Kretschmer, Nadine
Rosic, Gvozden
Selakovic, Dragica
Joksimovic, Jovana
Bauer, Rudolf
Issue Date: 2018
Abstract: © 2018 Elsevier Ltd Filipendula vulgaris Moench (dropwort) is used in traditional medicine for relieving various inflammation-related diseases. In the present study, the phytochemical profile of F. vulgaris aerial part (FVA) and root (FVR) methanolic extracts was evaluated by LC-DAD-HRMS analysis. Furthermore, their in vitro and in vivo anti-inflammatory effects, as well as their potential cytotoxicity, were assessed. Results showed that the extracts mainly contain phenolics like flavonoids, hydrolyzable tannins, procyanidins, and phenolic acid derivatives, including gaultherin. No in vitro cytotoxicity was found at the highest concentration (50 μg/mL). FVA extract (50 μg/mL) significantly inhibited cyclooxygenase-1 and -2 (COX-1 and COX-2) activities in vitro (>50% inhibition), and FVR extract considerably inhibited COX-2 activity (52.5 ± 2.7%) without affecting COX-2 gene expression in LPS-stimulated THP-1 cells. The extracts demonstrated prominent in vivo anti-inflammatory potential upon oral administration in rats. Especially FVA extract at 100 and 200 mg/kg significantly inhibited carrageenan-induced edema formation. From these results, it can be concluded that F. vulgaris extracts possess interesting anti-inflammatory properties.
Type: article
DOI: 10.1016/j.fct.2018.10.001
ISSN: 0278-6915
SCOPUS: 2-s2.0-85054743102
Appears in Collections:Faculty of Medical Sciences, Kragujevac
Faculty of Science, Kragujevac
Institute for Information Technologies, Kragujevac

Page views(s)




Files in This Item:
File Description SizeFormat 
  Restricted Access
29.86 kBAdobe PDFThumbnail

Items in SCIDAR are protected by copyright, with all rights reserved, unless otherwise indicated.