Please use this identifier to cite or link to this item: https://scidar.kg.ac.rs/handle/123456789/11720
Title: Vanillic aldehydes for the one-pot synthesis of novel 2-oxo-1,2,3,4-tetrahydropyrimidines
Authors: Muškinja, Jovana
Janković, Nenad
Ratković, Zoran
Bogdanovic, Goran A.
Bugarčić Z.
Issue Date: 2016
Abstract: © 2016, Springer International Publishing Switzerland. A small library of novel 2-oxo-1,2,3,4-tetrahydropyrimidines was synthesized via a one-pot multicomponent Biginelli reaction. Copper complex (PhNH3)2CuCl4, which was used for the first time as a homogeneous and heterogeneous catalyst, makes this a facile and efficient reaction at room temperature. All the obtained products fall out of the solution in pure form and are easily isolated via filtration in good-to-excellent yields. The molecular structure of one of the products, ethyl 6-methyl-2-oxo-4-(4′-isopropoxy-3′-methoxyphenyl) - 1,2,3,4 - tetrahydropyrimidine-5- carboxylate, has been determined by X-ray crystallography. All non-hydrogen atoms in the heterocyclic, six-membered ring are determined to be approximately coplanar.
URI: https://scidar.kg.ac.rs/handle/123456789/11720
Type: article
DOI: 10.1007/s11030-016-9658-y
ISSN: 1381-1991
SCOPUS: 2-s2.0-84977450850
Appears in Collections:Faculty of Science, Kragujevac
Institute for Information Technologies, Kragujevac

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