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|Title:||Dehydrozingerone based 1-acetyl-5-aryl-4,5-dihydro-1H-pyrazoles: Synthesis, characterization and anticancer activity|
Bogdanovic, Goran A.
Simovic Markovic, Bojana
Crossed D Signorcrossed D Signevic S.
|Abstract:||© 2016 Elsevier B.V. All rights reserved. A small series of 1-acetyl-5-aryl-4,5-dihydro-1H-pyrazoles (aryl = 4-hydroxy-3-methoxyphenyl and 4-alkoxy-3-methoxyphenyl) was prepared, starting from 4-(4-hydroxy-3-methoxyphenyl)-3-buten-2-one, dehydrozingerone, and its alkyl derivatives. Their in vitro cytotoxic activity against some cancer cell lines was tested, showing significant anticancer activity. All the new compounds were well characterized by IR, 1H, 13C NMR and ESI-MS spectroscopy and physical data, whereas structures of two of them were determined by single crystal X-ray analysis.|
|Appears in Collections:||Faculty of Medical Sciences, Kragujevac|
Faculty of Science, Kragujevac
Institute for Information Technologies, Kragujevac
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