Dehydrozingerone based 1-acetyl-5-aryl-4,5-dihydro-1H-pyrazoles: Synthesis, characterization and anticancer activity

Please use this identifier to cite or link to this item: https://scidar.kg.ac.rs/handle/123456789/11777

Title:	Dehydrozingerone based 1-acetyl-5-aryl-4,5-dihydro-1H-pyrazoles: Synthesis, characterization and anticancer activity
Authors:	Ratković, Zoran Muškinja, Jovana Burmudz̃ija A. Ranković B. Kosanic, Marijana Bogdanovic, Goran A. Simovic Markovic, Bojana Nikolić A. Arsenijevic, Nebojsa Crossed D Signorcrossed D Signevic S. Vukicevic R.
Issue Date:	2016
Abstract:	© 2016 Elsevier B.V. All rights reserved. A small series of 1-acetyl-5-aryl-4,5-dihydro-1H-pyrazoles (aryl = 4-hydroxy-3-methoxyphenyl and 4-alkoxy-3-methoxyphenyl) was prepared, starting from 4-(4-hydroxy-3-methoxyphenyl)-3-buten-2-one, dehydrozingerone, and its alkyl derivatives. Their in vitro cytotoxic activity against some cancer cell lines was tested, showing significant anticancer activity. All the new compounds were well characterized by IR, 1H, 13C NMR and ESI-MS spectroscopy and physical data, whereas structures of two of them were determined by single crystal X-ray analysis.
URI:	https://scidar.kg.ac.rs/handle/123456789/11777
Type:	article
DOI:	10.1016/j.molstruc.2015.12.079
ISSN:	0022-2860
SCOPUS:	2-s2.0-84953455358
Appears in Collections:	Faculty of Medical Sciences, Kragujevac Faculty of Science, Kragujevac Institute for Information Technologies, Kragujevac

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