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Title: Dehydrozingerone based 1-acetyl-5-aryl-4,5-dihydro-1H-pyrazoles: Synthesis, characterization and anticancer activity
Authors: Ratković, Zoran
Muškinja, Jovana
Burmudz̃ija A.
Ranković B.
Kosanic, Marijana
Bogdanovic, Goran A.
Simovic Markovic, Bojana
Nikolić A.
Arsenijevic, Nebojsa
Crossed D Signorcrossed D Signevic S.
Vukicevic R.
Issue Date: 2016
Abstract: © 2016 Elsevier B.V. All rights reserved. A small series of 1-acetyl-5-aryl-4,5-dihydro-1H-pyrazoles (aryl = 4-hydroxy-3-methoxyphenyl and 4-alkoxy-3-methoxyphenyl) was prepared, starting from 4-(4-hydroxy-3-methoxyphenyl)-3-buten-2-one, dehydrozingerone, and its alkyl derivatives. Their in vitro cytotoxic activity against some cancer cell lines was tested, showing significant anticancer activity. All the new compounds were well characterized by IR, 1H, 13C NMR and ESI-MS spectroscopy and physical data, whereas structures of two of them were determined by single crystal X-ray analysis.
Type: article
DOI: 10.1016/j.molstruc.2015.12.079
ISSN: 0022-2860
SCOPUS: 2-s2.0-84953455358
Appears in Collections:Faculty of Medical Sciences, Kragujevac
Faculty of Science, Kragujevac
Institute for Information Technologies, Kragujevac

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