Please use this identifier to cite or link to this item: https://scidar.kg.ac.rs/handle/123456789/12086
Title: Antioxidant and anticancer properties of leaves and seed cones from European yew (Taxus baccata L.)
Authors: Ćurčić Milutinović, Milena
Stanković, Milan
Cvetkovic, Danijela
Topuzovic, Marina
Mihailovic, Vladimir
Marković, Snežana
Journal: Archives of Biological Sciences
Issue Date: 1-Jan-2015
Abstract: Plant extracts of the leaves and seed cones of European yew Taxus baccata L. (Taxaceae) were analyzed for total phenolic content, flavonoid concentrations, antioxidant and anticancer properties (cytotoxic and proapoptotic activity). The total phenolic content ranged between 8.23 and 210.01 mg Ga/g, with the IC 50 values for antioxidant activity between 25.24 and 533.66 μg/ml. The MTT test showed that the methanolic extract of leaves had better activity on HCT-116 cells than the extract of seed cones, with IC 50 values of 14.3 for 24 h and 4.59 for 72 h. The MDA-MB-231 cell line displayed significantly lower sensitivity to both extracts as compared to the HCT-116 cell line. Microscopic examination indicated that the extracts induced apoptosis in both cell lines. These results suggest that T. baccata leaves and seed cones are a potential source of phenolic compounds, especially flavonoids, as natural antioxidant, cytotoxic and strong proapoptotic substances of high value.
URI: https://scidar.kg.ac.rs/handle/123456789/12086
Type: Article
DOI: 10.2298/ABS141006015M
ISSN: 03544664
SCOPUS: 84937406337
Appears in Collections:Faculty of Science, Kragujevac
Institute for Information Technologies, Kragujevac
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