Please use this identifier to cite or link to this item: https://scidar.kg.ac.rs/handle/123456789/12273
Title: Synthesis, characterization, thermal and DNA-binding properties of new zinc complexes with 2-hydroxyphenones
Authors: Mrkalić, Emina
Zianna A.
Psomas, George
Gdaniec, Maria
Czapik, Agnieszka
Coutouli-Argyropoulou E.
Lalia-Kantouri M.
Issue Date: 2014
Abstract: The neutral mononuclear zinc complexes with 2-hydroxyphenones (ketoH) having the formula [Zn(keto)2(H2O)2] and [Zn(keto)2(enR)], where enR stands for a N,N'-donor heterocyclic ligand such as 2,2′-bipyridine (bipy), 1,10-phenanthroline (phen) or 2,2′-dipyridylamine (dpamH), have been synthesized and characterized by IR, UV and 1H NMR spectroscopies. The 2-hydroxyphenones are chelated to the metal ion through the phenolate and carbonyl oxygen atoms. The crystal structures of [bis(2-hydroxy-4-methoxy-benzophenone)(2,2′-bipyridine) zinc(II)] dimethanol solvate and [bis(2-hydroxy-benzophenone)(2,2′- bipyridine)zinc(II)] dimethanol solvate have been determined by X-ray crystallography. The thermal stability of the zinc complexes has been investigated by simultaneous TG/DTG-DTA technique. The ability of the complexes to bind to calf-thymus DNA (CT DNA) has been studied by UV-absorption and fluorescence emission spectroscopy as well as viscosity measurements. UV studies of the interaction of the complexes with DNA have shown that they can bind to CT DNA and the corresponding binding constants to DNA have been calculated and evaluated. The complexes most probably bind to CT DNA via intercalation as concluded by studying the viscosity of a DNA solution in the presence of the complexes. Competitive studies with ethidium bromide (EB) have shown that the reported complexes can displace the DNA-bound EB, suggesting strong competition with EB for the intercalation site. © 2014 Published by Elsevier Inc.
URI: https://scidar.kg.ac.rs/handle/123456789/12273
Type: article
DOI: 10.1016/j.jinorgbio.2014.01.019
ISSN: 0162-0134
SCOPUS: 2-s2.0-84894451454
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