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Title: The subchronic effects of 3,4-methylendioxymethamphetamine on oxidative stress in rat brain
Authors: Simic, Ivan
Iric Cupic, Violeta
Vucic, Rada
Petrovic, Marina
Mladenovic, Violeta
Veselinović M.
Ignjatovic, Vladimir
Vučković, Jelena
Issue Date: 2014
Abstract: The aim of the present study was to evaluate the subchronic effects of 3,4-methylenedioxymethamphetamine on several oxidative stress markers: index of lipid peroxidation (ILP), superoxide dismutase (SOD) activity, superoxide radical (O2.-) levels, and reduced glutathione (GSH) levels in the frontal cortex, striatum and hippocampus of the rat. The study included 64 male Wistar rats (200-250 g). The animals were treated per os with of 5, 10, or 20 mg/kg of 3,4-methylenedioxymethamphetamine (MDMA) every day for 15 days. The subchronic administration of MDMA resulted in an increase in ILP, SOD and O2.-, and a decrease in GSH, from which we conclude that oxidative stress was induced in rat brain.
Type: article
DOI: 10.2298/ABS1403075S
ISSN: 0354-4664
SCOPUS: 2-s2.0-84908191587
Appears in Collections:Faculty of Medical Sciences, Kragujevac

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