Please use this identifier to cite or link to this item: https://scidar.kg.ac.rs/handle/123456789/12430
Title: Enhanced anti-diabetogenic effect of intravenous immune globulin modified by ferrous ion exposure
Authors: Pavlovic S.
Zdravkovic, Nemanja
Pejnović, Nada
Djoumerska-Aleksieva I.
Arsenijevic, Nebojsa
Vassilev T.
Lukic, Miodrag
Issue Date: 2014
Abstract: The aim of this study was to investigate the immunomodulatory capacity of native and Fe(II)-exposed intravenous immune globulin (IVIg) in multiple low dose streptozotocin-induced diabetes and to delineate the mechanisms of their influence on immune cell functions. Optimal doses (200-600mg/kg) of IVIg prevented the development of hyperglycemia, glycosuria and attenuated mononuclear cell infiltration in pancreatic islets. Fe(II) exposure of IVIg decreased their optimal therapeutic dose to 100mg/kg which significantly decreased the serum levels of proinflammatory cytokines compared to the same dose of native IVIg. This was accompanied by lower numbers of TNF-α, IFN-γ and IL-17 producing CD4+ T cells and increased frequencies of CD4+IL-10+ and CD4+IL-4 + T cells in the pancreatic lymph nodes and islets on day 16 after diabetes induction. Ferrous ion-exposed IVIg enhanced the bias towards Th2 response while the regulatory Foxp3+ T cells were not affected. Copyright © by BIOLIFE, s.a.s.
URI: https://scidar.kg.ac.rs/handle/123456789/12430
Type: article
DOI: 10.1177/1721727X1401200107
ISSN: 1721-727X
SCOPUS: 2-s2.0-84899052009
Appears in Collections:Faculty of Medical Sciences, Kragujevac

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