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dc.rights.licenseopenAccess-
dc.contributor.authorFilipovic, Nenad-
dc.contributor.authorGibney B.-
dc.contributor.authorKojić M.-
dc.contributor.authorNikolic, Dalibor-
dc.contributor.authorIsailovic, Velibor-
dc.contributor.authorYsasi, Alexandra-
dc.contributor.authorKonerding M.-
dc.contributor.authorMentzer S.-
dc.contributor.authorTSUDA A.-
dc.date.accessioned2021-04-20T21:00:49Z-
dc.date.available2021-04-20T21:00:49Z-
dc.date.issued2013-
dc.identifier.issn8750-7587-
dc.identifier.urihttps://scidar.kg.ac.rs/handle/123456789/12511-
dc.description.abstractIn many mammalian species, the removal of one lung [pneumonectomy (PNX)] is associated with the compensatory growth of the remaining lung. To investigate the hypothesis that parenchymal deformation may trigger lung regeneration, we used respiratorygated micro-computed tomography scanning to create threedimensional finite-element geometric models of the murine cardiac lobe with cyclic breathing. Models were constructed of respiratorygated micro-computed tomography scans pre-PNX and 24 h post- PNX. The computational models demonstrated that the maximum stretch ratio map was patchy and heterogeneous, particularly in subpleural, juxta-diaphragmatic, and cephalad regions of the lobe. In these parenchymal regions, the material line segments at peak inspiration were frequently two- to fourfold greater after PNX; some regions of the post-PNX cardiac lobe demonstrated parenchymal compression at peak inspiration. Similarly, analyses of parenchymal maximum shear strain demonstrated heterogeneous regions of mechanical stress with focal regions demonstrating a threefold increase in shear strain after PNX. Consistent with previously identified growth patterns, these subpleural regions of enhanced stretch and shear strain are compatible with a mechanical signal, likely involving cyclic parenchymal stretch, triggering lung growth. Copyright © 2013 the American Physiological Society.-
dc.rightsinfo:eu-repo/semantics/openAccess-
dc.rightsinfo:eu-repo/semantics/openAccess-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/-
dc.sourceJournal of Applied Physiology-
dc.titleMapping cyclic stretch in the postpneumonectomy murine lung-
dc.typearticle-
dc.identifier.doi10.1152/japplphysiol.00635.2013-
dc.identifier.scopus2-s2.0-84887060429-
Налази се у колекцијама:Faculty of Engineering, Kragujevac
Institute for Information Technologies, Kragujevac

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