Please use this identifier to cite or link to this item: https://scidar.kg.ac.rs/handle/123456789/12917
Title: Influence of cytokines on the postoperative period
Authors: Jovanovic D.
Milovanovic, Dragan
Jovanovic I.
Folic, Marko
Jakovljevic V.
Journal: Clinical and Experimental Obstetrics and Gynecology
Issue Date: 15-Feb-2020
Abstract: © 2020 Jovanovic et al. Purpose of Investigation: The relationships between postoperative recovery and changes of circulating levels of pro- and anti-in- flammatory cytokines. Materials and Methods: The study included prospectively a cohort of 51 females who underwent abdominal hys- terectomy for benign diseases. Recovery was assessed with Quality of Recovery 40 (QoR-40) questionnaire and concentrations of four cytokines during the 72-hours period were measured using human sensitive enzyme-linked immunosorbent assay (ELISA) kits. Results: Total QoR-40 score significantly declined on the first and the second postoperative days and then returned to baseline (p < 0.001). Interleukin-17 serum levels had no significant trend (p = 0.072). Statistically significant patterns of concentration changes of interferon gamma (p = 0.010), interleukin-10 (p < 0.001), and transforming growth factor (p = 0.016) were found. There were no significant cor- relations between QoR-40 scores and concentrations of any cytokine, at prespecified study power for moderate relationships at least. Conclusion: Recovery after abdominal hysterectomy was rapid and complete and it was unrelated to serum concentration profiles of examined cytokines.
URI: https://scidar.kg.ac.rs/handle/123456789/12917
Type: article
DOI: 10.31083/j.ceog.2020.01.4963
ISSN: 03906663
SCOPUS: 85082139356
Appears in Collections:Faculty of Medical Sciences, Kragujevac

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