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Title: The significant role of dietary intake of vitamin D in non-menopausal women health
Authors: Milovanovic, Jasmina
Milovanovic, Olivera
Tomic Lucic, Aleksandra
Djokovic, Jelena
Cvetkovic O.
Živanović, Slavoljub
Barjaktarevic A.
Pantović M.
Radovanovic, Milan
Dimitrijevic, Aleksandra
Jankovic A.
Veličković-Radovanović R.
Issue Date: 2021
Abstract: Optimal vitamin D status is very important for reflecting not only bone but overall woman’s health. The aim of the study was to determine pharmacokinetic variability of 25-hydroxy vitamin D, to reveal and quantify the most significant factors that affect its variability in the population of healthy non-menopausal women using the population pharmacokinetic (PopPK) approach. The study population consisted of 74 healthy reproductive women aged from 35 to 50 years, without the use of any supplement. A population pharmacokinetics analysis was conducted using a nonlinear mixed-effects model software. A total of 35 factors were assessed: demographic, clinical, biochemical data and lifestyle factors. The average age and bodyweight of our participants were 40.11 ± 4.35 years 65.30 ± 6.80 kg, respectively. The observed mean serum concentration of 25-hydroxy vitamin D was 26.51 ± 13.49 ng/mL with a wide range of 6.97 to 59.89 ng/mL. Development final PopPK model of the clearance of 25-hydroxy vitamin D showed that only the average daily dose of vitamin D intake from food had a significant influence, with a magnitude of its effects of 0.00401. These results could help when individualizing vitamin D intake in the form of supplements, especially during the wintertime, in healthy reproductive women.
Type: article
DOI: 10.1080/03630242.2021.1917480
ISSN: 0363-0242
SCOPUS: 2-s2.0-85105166528
Appears in Collections:Faculty of Medical Sciences, Kragujevac

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