Please use this identifier to cite or link to this item: https://scidar.kg.ac.rs/handle/123456789/13730
Title: Neuroinflammation in autism and supplementation based on omega-3 polyunsaturated fatty acids: A narrative review
Authors: Veselinovic, Aleksandar
Petrović, Snježana
Žikić V.
Subotić M.
Jakovljevic, Vladimir
Jeremic, Nevena
Vucic, Vesna
Journal: Medicina (Lithuania)
Issue Date: 1-Sep-2021
Abstract: Autism Spectrum Disorder (ASD) is a complex neurodevelopmental disorder characterized by persistent deficits in social communication and social interaction across multiple contexts and restricted, repetitive patterns of behavior, interests and activities. The maternal status of polyunsaturated fatty acids (PUFA) regulates microglial activity and neuroinflammatory pathways during a child’s brain development. In children with ASD, the metabolism of PUFA is thought to be deficient or abnormal, leading to increased production of proinflammatory cytokines, increased oxidative stress and an imbalance in the formation and action of neurotransmitters. In addition, nutritional deficits in omega-3 PUFA may affect gut microbiota and contribute to ASD by the gut–brain axis. The aim of this study was to review the possible role of neuroinflammation in ASD development and the effect of omega-3 PUFA supplementation in children with ASD. Due to a wide heterogeneity across RCTs, no definitive conclusion about omega-3 PUFA effects in ASD can be drawn. Supplemen-tation with PUFA could be considered as one of the aspects in regulating the biological status of the organism and could provide added value to standard medical and psychological interventions for reducing behavioral deficits.
URI: https://scidar.kg.ac.rs/handle/123456789/13730
Type: Review
DOI: 10.3390/medicina57090893
ISSN: 1010660X
SCOPUS: 85114289550
Appears in Collections:Faculty of Medical Sciences, Kragujevac
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