Please use this identifier to cite or link to this item: https://scidar.kg.ac.rs/handle/123456789/14073
Title: Human Embryos, Induced Pluripotent Stem Cells, and Organoids: Models to Assess the Effects of Environmental Plastic Pollution
Authors: Miloradovic D.
Pavlovic D.
Gazdic, Marina
Nikolic G.
Papic, Milos
Milivojevic N.
Stojković M.
Ljujic, Biljana
Issue Date: 2021
Abstract: For a long time, animal models were used to mimic human biology and diseases. However, animal models are not an ideal solution due to numerous interspecies differences between humans and animals. New technologies, such as human-induced pluripotent stem cells and three-dimensional (3D) cultures such as organoids, represent promising solutions for replacing, refining, and reducing animal models. The capacity of organoids to differentiate, self-organize, and form specific, complex, biologically suitable structures makes them excellent in vitro models of development and disease pathogenesis, as well as drug-screening platforms. Despite significant potential health advantages, further studies and considerable nuances are necessary before their clinical use. This article summarizes the definition of embryoids, gastruloids, and organoids and clarifies their appliance as models for early development, diseases, environmental pollution, drug screening, and bioinformatics.
URI: https://scidar.kg.ac.rs/handle/123456789/14073
Type: review
DOI: 10.3389/fcell.2021.709183
SCOPUS: 2-s2.0-85115169526
Appears in Collections:Faculty of Medical Sciences, Kragujevac

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