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Title: Evaluation of antioxidant and cytotoxic properties of phenolic N-acylhydrazones: Structure-activity relationship
Authors: Branković J.
Milivojevic N.
Milovanović, Vesna
Simijonović, Dušica
Petrović, Zorica
Marković, Zoran
Šeklić, Dragana
Živanović, Marko
Vukić, Milena
Petrović, Vladimir
Journal: Royal Society Open Science
Issue Date: 1-Jan-2022
Abstract: Cancer is still a relentless public health issue. Particularly, colorectal cancer is the third most prevalent cancer in men and the second in women. Moreover, cancer development and growth are associated with various cell disorders, such as oxidative stress and inflammation. The quest for efficient therapeutics is a challenging task, especially when it comes to achieving both cytotoxicity and selectivity. Herein, five series of phenolic N-acylhydrazones were synthesized and evaluated for their antioxidant potency, as well as their influence on HCT-116 and MRC-5 cells viability. Among 40 examined analogues, 20 of them expressed antioxidant activity against the DPPH radical. Furthermore, density functional theory was employed to estimate the antioxidant potency of the selected analogues from the thermodynamical aspect, as well as the preferable free-radical scavenging pathway. Cytotoxicity assay exposed enhanced selectivity of a number of analogues toward cancer cells. The structure-activity analysis revealed the impact of the type and position of the functional groups on both cell viability and selectivity toward cancer cells.
Type: journal article
DOI: 10.1098/rsos.211853
SCOPUS: 85132224447
Appears in Collections:Faculty of Science, Kragujevac

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