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https://scidar.kg.ac.rs/handle/123456789/15598
Title: | Comparison of Numerical Model with Experimental Measurements for the Purpose of Testing Partially and Fully Biodegradable Stents |
Authors: | Filipovic, Nenad ![]() ![]() |
Issue Date: | 2023 |
Abstract: | Atherosclerosis is a progressive disease characterized by the accumulation of lipids and fibrous elements in the arterial wall. This accumulation produces plaque in the arteries. Percutaneous transluminal coronary angioplasty (PTCA) is a minimally invasive procedure that opens narrowed coronary arteries because of the plaque growth. A medical device that can hold an artery open in the area of narrowing is called a stent and it usually resembles a mesh tube. Mechanical stent testDevicess are standard preclinical procedure used to simulate stent behavior for different physiological conditions. In this research, a mechanical testDevices called three-point bending testDevices was performed on a partially and fully bioresorbable vascular scaffold (BVS) manufactured by Boston Scientific Limited [1]. Poly-l-lactic acid (PLLA) material model was implemented for the numerical model inside in-house PAK [2] software. Measurements obtained by mechanical testing were compared with the numerical results. There is a strong correlation between the numerical simulation and real experiments with a coefficient of determination (R2) > 0.99 and a correlation coefficient (R) > 0.99. It can be concluded that in silico mechanical tests can partially or fully replace in vitro stent tests, which can open a new avenue for regulatory submission and change regulatory ISO standard procedures. |
URI: | https://scidar.kg.ac.rs/handle/123456789/15598 |
Type: | bookPart |
DOI: | 10.1007/978-3-031-17269-4_11 |
ISSN: | 1612-1317 |
SCOPUS: | 2-s2.0-85145777130 |
Appears in Collections: | Faculty of Engineering, Kragujevac |
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File | Description | Size | Format | |
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PaperMissing.pdf Restricted Access | 29.86 kB | Adobe PDF | ![]() View/Open |
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