Please use this identifier to cite or link to this item: https://scidar.kg.ac.rs/handle/123456789/15645
Title: Numerical Modeling of Particle Dynamics Inside a Dry Powder Inhaler
Authors: Sustersic, Tijana
Bodić, Aleksandar
Ignjatović, Jelisaveta
Cvijic, Sandra
Ibric, Svetlana
Filipovic, Nenad
Issue Date: 2022
Abstract: The development of novel dry powders for dry powder inhalers (DPIs) requires the in vitro assessment of DPI aerodynamic performance. As a potential complementary method, in silico numerical simulations can provide additional information about the mechanisms that guide the particles and their behavior inside DPIs. The aim of this study was to apply computational fluid dynamics (CFDs) coupled with a discrete phase model (DPM) to describe the forces and particle trajectories inside the RS01® as a model DPI device. The methodology included standard fluid flow equations but also additional equations for the particle sticking mechanism, as well as particle behavior after contacting the DPI wall surface, including the particle detachment process. The results show that the coefficient of restitution between the particle and the impact surface does not have a high impact on the results, meaning that all tested combinations gave similar output efficiencies and particle behaviors. No sliding or rolling mechanisms were observed for the particle detachment process, meaning that simple bouncing off or deposition particle behavior is present inside DPIs. The developed methodology can serve as a basis for the additional understanding of the particles’ behavior inside DPIs, which is not possible using only in vitro experiments; this implies the possibility of increasing the efficiency of DPIs.
URI: https://scidar.kg.ac.rs/handle/123456789/15645
Type: article
DOI: 10.3390/pharmaceutics14122591
ISSN: -
SCOPUS: 2-s2.0-85144880150
Appears in Collections:Faculty of Engineering, Kragujevac

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