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Title: Colicins and Microcins Produced by Enterobacteriaceae: Characterization, Mode of Action, and Putative Applications
Authors: Mladenovic, Katarina
Grujović, Mirjana
Koracévic M.
Nikodijević, Danijela
Ćurčić Milutinović, Milena
Semedo-Lemsaddek, Teresa
Djilas, Milan
Issue Date: 2022
Abstract: Enterobacteriaceae are widely present in many environments related to humans, including the human body and the food that they consume, from both plant or animal origin. Hence, they are considered relevant members of the gastrointestinal tract microbiota. On the other hand, these bacteria are also recognized as putative pathogens, able to impair human health and, in food, they are considered indicators for the microbiological quality and hygiene status of a production process. Nevertheless, beneficial properties have also been associated with Enterobacteriaceae, such as the ability to synthesize peptides and proteins, which can have a role in the structure of microbial communities. Among these antimicrobial molecules, those with higher molecular mass are called colicins, while those with lower molecular mass are named microcins. In recent years, some studies show an emphasis on molecules that can help control the development of pathogens. However, not enough data are available on this subject, especially related to microcins. Hence, this review gathers and summarizes current knowledge on colicins and microcins, potential usage in the treatment of pathogen-associated diseases and cancer, as well as putative applications in food biotechnology.
Type: review
DOI: 10.3390/ijerph191811825
ISSN: 1661-7827
SCOPUS: 2-s2.0-85138412062
Appears in Collections:Faculty of Science, Kragujevac
Institute for Information Technologies, Kragujevac

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