Please use this identifier to cite or link to this item: https://scidar.kg.ac.rs/handle/123456789/17080
Title: Application of Machine Learning for Segmentation of the Pulmonary Acinus Imaged by Synchrotron X-Ray Tomography
Authors: Arsić, Branko
Saveljic, Igor
Henry, Frank S
Filipovic, Nenad
Tsuda, Akira
Journal: Journal of aerosol medicine and pulmonary drug delivery
Issue Date: 2023
Abstract: Background: To assess the effectiveness of inhalation therapy, it is important to evaluate the lungs' structure; thus, visualization of the entire lungs at the level of the alveoli is necessary. To achieve this goal, the applied visualization technique must satisfy the following two conditions simultaneously: (1) it has to obtain images of the entire lungs, since one part of the lungs is influenced by the other parts, and (2) the images have to capture the detailed structure of the alveolus/acinus in which gas exchange occurs. However, current visualization techniques do not fulfill these two conditions simultaneously. Segmentation is a process in which each pixel of the obtained high-resolution images is simplified (i.e., the representation of an image is changed by categorizing and modifying each pixel) so that we can perform three-dimensional volume rendering. One of the bottlenecks of current approaches is that the accuracy of the segmentation of each image has to be evaluated on the outcome of the process (mainly by an expert). It is a formidable task to evaluate the astronomically large numbers of images that would be required to resolve the entire lungs in high resolution. Methods: To overcome this challenge, we propose a new approach based on machine learning (ML) techniques for the validation step. Results: We demonstrate the accuracy of the segmentation process itself by comparison with previously validated images. In this ML approach, to achieve a reasonable accuracy, millions/billions of parameters used for segmentation have to be optimized. This computationally demanding new approach is achievable only due to recent dramatic increases in computation power. Conclusion: The objective of this article is to explain the advantages of ML over the classical approach for acinar imaging.
URI: https://scidar.kg.ac.rs/handle/123456789/17080
Type: article
DOI: 10.1089/jamp.2022.0051
ISSN: 1941-2711
Appears in Collections:Faculty of Science, Kragujevac

Page views(s)

43

Downloads(s)

15

Files in This Item:
File Description SizeFormat 
jamp.2022.0051-1.pdf484.56 kBAdobe PDFThumbnail
View/Open


This item is licensed under a Creative Commons License Creative Commons