Please use this identifier to cite or link to this item: https://scidar.kg.ac.rs/handle/123456789/17222
Title: Synthesis and biological activity of novel zingerone-thiohydantoin hybrids
Authors: Virijevic, Katarina
Stanić, Petar
Muškinja, Jovana
Katanić Stanković, Jelena S.
Sreckovic, Nikola
Živanović, Marko
Šmit, Biljana
Issue Date: 2022
Abstract: A series of zingerone-thiohydantoin hybrids were synthesized from O-alkyl zingerone derivatives by cyclocondensation with thiosemicarbazide in a two-step reaction. Obtained new potentially bioactive compounds were structurally characterized by IR and NMR spectroscopy, as well as elemental and HRMS analysis. In addition, their antimicrobial and in vitro anticancer activities were tested. Tested compounds showed low to moderate antimicrobial activity. Zingerone-thiohydantoin hybrid with an O-buthyl substituent exerted the significant cytotoxic activity on colon HCT-116 cancer cells without toxicity on healthy MRC-5 cells.
URI: https://scidar.kg.ac.rs/handle/123456789/17222
Type: article
DOI: 10.2298/JSC220404047V
ISSN: 0352-5139
Appears in Collections:Faculty of Science, Kragujevac
Institute for Information Technologies, Kragujevac

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