ANTIMICROBIAL ACTIVITY OF OS(II) COMPLEXES CONTAINING N,N,N-INERT LIGANDS DERIVATES OF PYRAZYL-PYRIDINE

Abstract

Complexes of transition metals, including osmium complexes, are recognized for their good antitumor activity. Osmium complexes are considered to be potential anticancer agents with some of them also having potential as antimicrobial agents. Therefore, we have examined the antimicrobial activity of Os(II) complexes with N,N,N-inert ligands derivates of pyrazyl-pyridine that showed good anticancer activity. Antimicrobial activity was tested by determining the minimum inhibitory concentrations (MIC) and minimum microbicidal concentration (MMC) using the microdilution plate method for four gram-positive and three gram-negative bacteria, one probiotic, and one yeast. Gram-positive bacteria showed the highest sensitivity except for the isolate S. aureus. MIC was in the range of <3.9 to >1000 μg/mL. The highest resistance was shown by the yeast Candida albicans ATCC 10231. Os3 is distinguished from the examined complexes by the strength of the antimicrobial activity. In the activity of this complex, there are no differences in the action between Gram-positive and Gram-negative bacteria. Os3 on bacteria operates in the range of <7.8 for MIC to 250 μg/mL for MMC