Please use this identifier to cite or link to this item: https://scidar.kg.ac.rs/handle/123456789/19284
Title: ANTIMICROBIAL ACTIVITY OF OS(II) COMPLEXES CONTAINING N,N,N-INERT LIGANDS DERIVATES OF PYRAZYL-PYRIDINE
Authors: Bogojeski, Jovana
Cakovic, Angelina
Petrović, Biljana
Jovanović Stević, Snežana
Kesić, Ana
Radisavljević, Snežana
Ćoćić, Dušan
Sretenović, Snežana
Rakovic, Ivana
Radojevic, Ivana
Markpvić, Katarina
Grujović, Mirjana
Issue Date: 2023
Abstract: Complexes of transition metals, including osmium complexes, are recognized for their good antitumor activity. Osmium complexes are considered to be potential anticancer agents with some of them also having potential as antimicrobial agents. Therefore, we have examined the antimicrobial activity of Os(II) complexes with N,N,N-inert ligands derivates of pyrazyl-pyridine that showed good anticancer activity. Antimicrobial activity was tested by determining the minimum inhibitory concentrations (MIC) and minimum microbicidal concentration (MMC) using the microdilution plate method for four gram-positive and three gram-negative bacteria, one probiotic, and one yeast. Gram-positive bacteria showed the highest sensitivity except for the isolate S. aureus. MIC was in the range of <3.9 to >1000 μg/mL. The highest resistance was shown by the yeast Candida albicans ATCC 10231. Os3 is distinguished from the examined complexes by the strength of the antimicrobial activity. In the activity of this complex, there are no differences in the action between Gram-positive and Gram-negative bacteria. Os3 on bacteria operates in the range of <7.8 for MIC to 250 μg/mL for MMC
URI: https://scidar.kg.ac.rs/handle/123456789/19284
Type: conferenceObject
Appears in Collections:Institute for Information Technologies, Kragujevac

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