Please use this identifier to cite or link to this item: https://scidar.kg.ac.rs/handle/123456789/19481
Title: GALLIC ACID HYDRAZONES: ‘IN SILICO’ INHIBITION OF THIOREDOXIN REDUCTASE
Authors: Branković, Jovica
Milovanović, Vesna
Petrović, Zorica D.
Petrović, Vladimir P.
Issue Date: 2021
Abstract: Gallic hydrazones, as gallic acid derivatives, are known as pharmacophores of numerous multipotent agents. Among them, antiproliferative activity is one of the most important. On the other hand, thioredoxin reductase (TrxR1) is a part of the thioredoxin system, one of the most important systems responsible for maintaining the redox equilibrium inside the cell. It is overexpressed in different forms of tumors. Bearing this in mind, TrxR1 is a valid target for the development of compounds with potential antiproliferative activity. For this purpose, eight gallic acid-based hydrazones are selected and examined in silico for their potential inhibitory activity towards TrxR1
URI: https://scidar.kg.ac.rs/handle/123456789/19481
Type: conferenceObject
DOI: 10.46793/ICCBI21.320B
Appears in Collections:Faculty of Agronomy, Čačak
Faculty of Science, Kragujevac

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