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Title: Murine cytomegalovirus infection induces susceptibility to EAE in resistant BALB/c mice
Authors: Milovanovic, Jelena
Popović B.
Milovanovic, Marija
Kvestak D.
Arsenijevic A.
Stojanovic B.
Tanaskovic, Irena
Krmpotic A.
Arsenijevic, Nebojsa
Jonjic S.
Lukic, Miodrag
Issue Date: 2017
Abstract: © 2017 Milovanovic, Popovic, Milovanovic, Kvestak, Arsenijevic, Stojanovic, Tanaskovic, Krmpotic, Arsenijevic, Jonjic and Lukic. In contrast to C57BL/6 mice, BALB/c mice are relatively resistant to the induction of experimental autoimmune encephalomyelitis (EAE) after challenge with MOG35-55 peptide. Here, we provide the first evidence that infection with murine cytomegalovirus (MCMV) in adulthood abrogates this resistance. Infected BALB/c mice developed clinical and histological signs similar to those seen in susceptible C57BL/6 mice. In addition to CD4+ cells, large proportion of cells in the infiltrate of diseased BALB/c mice was CD8+, similar with findings in multiple sclerosis. CD8+ cells that responded to ex vivo restimulation with MOG35-55 were not specific for viral epitopes pp89 and m164. MCMV infection favors proinflammatory type of dendritic cells (CD86+CD40+CD11c+) in the peripheral lymph organs, M1 type of microglia in central nervous system, and increases development of Th1/Th17 encephalitogenic cells. This study indicates that MCMV may enhance autoimmune neuropathology and abrogate inherent resistance to EAE in mouse strain by enhancing proinflammatory phenotype of antigen-presenting cells, Th1/Th17, and CD8 response to MOG35-55.
Type: article
DOI: 10.3389/fimmu.2017.00192
SCOPUS: 2-s2.0-85014309070
Appears in Collections:Faculty of Medical Sciences, Kragujevac

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