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Title: Synthesis, characterization, and cytotoxicity of a Novel Gold(III) complex with O, O′-diethyl ester of ethylenediamine-N, N′-Di-2-(4-Methyl)Pentanoic acid
Authors: Pantelić N.
Zmejkovski B.
Markovic D.
Vujić, Jelena
Stanojkovic, Tatjana
Sabo, Tibor
Kaluđerović, Goran
Issue Date: 2016
Abstract: © 2016 by the authors; licensee MDPI, Basel, Switzerland. A novel gold(III) complex, [AuCl2{(S, S)-Et2eddl}]PF6, ((S, S)-Et2eddl = O, O′-diethyl ester of ethylenediamine-N, N′-di-2-(4-methyl)pentanoic acid) was synthesized and characterized by IR, 1D (1H and13C), and 2D (H, H-COSY and H, H-NOESY) NMR spectroscopy, mass spectrometry, and elemental analysis. Density functional theory calculations confirmed that (R, R)-N, N′ diastereoisomer was energetically the most stable isomer. In vitro antitumor action of ligand precursor [(S, S)-H2Et2eddl]Cl2 and corresponding gold(III) complex was determined against tumor cell lines: human adenocarcinoma (HeLa), human colon carcinoma (LS174), human breast cancer (MCF7), non-small cell lung carcinoma cell line (A549), and non-cancerous cell line human embryonic lung fibroblast (MRC-5) using microculture tetrazolium test (MTT) assay. The results indicate that both ligand precursor and gold(III) complex have showed very good to moderate cytotoxic activity against all tested malignant cell lines. The highest activity was expressed by [AuCl2{(S, S)-Et2eddl}]PF6 against the LS174 cells, with IC50 value of 7.4 ± 1.2 µM.
Type: article
DOI: 10.3390/met6090226
SCOPUS: 2-s2.0-85006722238
Appears in Collections:Faculty of Agronomy, Čačak

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