Please use this identifier to cite or link to this item: https://scidar.kg.ac.rs/handle/123456789/9435
Title: Effects of DL-homocysteine thiolactone on cardiac contractility, coronary flow, and oxidative stress markers in the isolated rat heart: The role of different gasotransmitters
Authors: Zivkovic V.
Jakovljevic V.
Pechanova O.
Srejovic I.
Joksimovic, Jovana
Selakovic, Dragica
Barudzic N.
Djuric D.
Journal: BioMed Research International
Issue Date: 1-Dec-2013
Abstract: Considering the adverse effects of DL-homocysteine thiolactone hydrochloride (DL-Hcy TLHC) on vascular function and the possible role of oxidative stress in these mechanisms, the aim of this study was to assess the influence of DL-Hcy TLHC alone and in combination with specific inhibitors of important gasotransmitters, such as L-NAME, DL-PAG, and PPR IX, on cardiac contractility, coronary flow, and oxidative stress markers in an isolated rat heart. The hearts were retrogradely perfused according to the Langendorff technique at a 70 cm H and administered 10 M DL-Hcy TLHC alone or in combination with 30 M L-NAME, 10 M DL-PAG, or 10 M PPR IX. The following parameters were measured: dp/dt max, dp/dt min, SLVP, DLVP, MBP, HR, and CF. Oxidative stress markers were measured spectrophotometrically in coronary effluent through TBARS, NO O 2 -, and Hconcentrations. The administration of DL-Hcy TLHC alone decreased dp/dt max, SLVP, and CF but did not change any oxidative stress parameters. DL-Hcy TLHC with L-NAME decreased CF, O 2 -, H and TBARS. The administration of DL-Hcy TLHC with DL-PAG significantly increased dp/dt max but decreased DLVP, CF, and TBARS. Administration of DL-Hcy TLHC with PPR IX caused a decrease in dp/dt max, SLVP, HR, CF, and TBARS. © 2013 Vladimir Zivkovic et al.
URI: https://scidar.kg.ac.rs/handle/123456789/9435
Type: Article
DOI: 10.1155/2013/318471
ISSN: 23146133
SCOPUS: 84893788993
Appears in Collections:Faculty of Medical Sciences, Kragujevac
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