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Title: The cytotoxicity of korbazol against murine cancer cell lines
Authors: Popovic, Suzana
Baskić D.
Zelen I.
Djurdjevic, Predrag
Zaric, Milan
Avramovic D.
Arsenijevic, Nebojsa
Issue Date: 2012
Abstract: Background/aim: Korbazol is a natural product that has been shown to exert cytotoxic eff ects on leukemic cells in vitro. The cytotoxicity and biochemical eff ects induced by Korbazol were investigated in the murine cell lines 4T1, B16 and BCL1. Methods: The cytotoxic activity of the tested compound was assessed using a colorimetric MTT assay. The concentration of the superoxide anion radical (O 2.-) and the activity of superoxide dismutase (SOD) in the samples were determined using spectrophotometric methods. The MDA content was determined using a TBA assay. Results: We found that Korbazol induced cell toxicity, an increased the concentration of the lipid peroxidation end product MDA, decreased superoxide dismutase activity and increased superoxide anion formation. Conclusions: Altogether, these results suggest that oxidative stress is involved in Korbazol-induced cytotoxicity in the investigated cell lines.
Type: article
DOI: 10.5937/SJECR13-2019
ISSN: 1820-8665
SCOPUS: 2-s2.0-84863815563
Appears in Collections:Faculty of Medical Sciences, Kragujevac

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