Please use this identifier to cite or link to this item: https://scidar.kg.ac.rs/handle/123456789/9614
Title: Lipid peroxidative damage on cisplatin exposure and alterations in antioxidant defense system in rat kidneys: A possible protective effect of selenium
Authors: Ognjanovic, Branka
Djordjevic, Natasa
Matić, Miloš
Obradović, Jasmina
Mladenovic J.
Štajn A.
Saicic Z.
Journal: International Journal of Molecular Sciences
Issue Date: 1-Feb-2012
Abstract: Cisplatin (Cis-diamminedichloroplatinum II, CP) is an important chemotherapeutic agent, useful in the treatment of several cancers, but with several side effects such as nephrotoxicity. The present study investigated the possible protective effect of selenium (Se) against CP-induced oxidative stress in the rat kidneys. Male Wistar albino rats were injected with a single dose of cisplatin (7 mg CP/kg b.m., i.p.) and selenium (6 mg Se/kg b.m, as Na 2SeO 3, i.p.), alone or in combination. The obtained results showed that CP increased lipid peroxidation (LPO) and decreased reduced glutathione (GSH) concentrations, suggesting the CP-induced oxidative stress, while Se treatment reversed this change to control values. Acute intoxication of rats with CP was followed by statistically significant decreased activity of antioxidant defense enzymes: superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px), glutathione reductase (GR) and glutathione-S-transferase (GST). Treatment with Se reversed CP-induced alterations of antioxidant defense enzyme activities and significantly prevented the CP-induced kidney damage. © 2012 by the authors; licensee MDPI, Basel, Switzerland.
URI: https://scidar.kg.ac.rs/handle/123456789/9614
Type: Article
DOI: 10.3390/ijms13021790
SCOPUS: 84857682442
Appears in Collections:Faculty of Science, Kragujevac
Institute for Information Technologies, Kragujevac
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