Please use this identifier to cite or link to this item: https://scidar.kg.ac.rs/handle/123456789/9666
Title: Antioxidant, antimicrobial and antiproliferative activities of five lichen species
Authors: Mitrovic, Tatjana
Stamenković P.
Cvetković V.
Tosic I.
Stankovíc M.
Radojevic, Ivana
Stefanović, Olgica
Čomić, Ljiljana
Šeklić, Dragana
Ćurčić Milutinović, Milena
Marković, Snežana
Journal: International Journal of Molecular Sciences
Issue Date: 1-Aug-2011
Abstract: The antioxidative, antimicrobial and antiproliferative potentials of the methanol extracts of the lichen species Parmelia sulcata, Flavoparmelia caperata, Evernia prunastri, Hypogymnia physodes and Cladonia foliacea were evaluated. The total phenolic content of the tested extracts varied from 78.12 to 141.59 mg of gallic acid equivalent (GA)/g of extract and the total flavonoid content from 20.14 to 44.43 mg of rutin equivalent (Ru)/g of extract. The antioxidant capacities of the lichen extracts were determined by 2,2-diphenyl-1-picrylhydrazyl (DPPH) radicals scavenging. Hypogymnia physodes with the highest phenolic content showed the strongest DPPH radical scavenging effect. Further, the antimicrobial potential of the lichen extracts was determined by a microdilution method on 29 microorganisms, including 15 strains of bacteria, 10 species of filamentous fungi and 4 yeast species. A high antimicrobial activity of all the tested extracts was observed with more potent inhibitory effects on the growth of Gram (+) bacteria. The highest antimicrobial activity among lichens was demonstrated by Hypogymnia physodes and Cladonia foliacea. Finally, the antiproliferative activity of the lichen extracts was explored on the colon cancer adenocarcinoma cell line HCT-116 by MTT (3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide) viability assay and acridine orange/ethidium bromide staining. The methanol extracts of Hypogymnia physodes and Cladonia foliacea showed a better cytotoxic activity than the other extracts. All lichen species showed the ability to induce apoptosis of HCT-116 cells. © 2011 by the authors; licensee MDPI, Basel, Switzerland.
URI: https://scidar.kg.ac.rs/handle/123456789/9666
Type: article
DOI: 10.3390/ijms12085428
SCOPUS: 80052173478
Appears in Collections:Faculty of Science, Kragujevac
Institute for Information Technologies, Kragujevac

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