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Title: Genotoxic potential of Cotinus coggygriascop. (Anacardiaceae) stem extract in vivo
Authors: Matić, Sanja
Stanić S.
Bogojević, Desanka
Solujic A.
Grdovic N.
Vidaković, Melita
Mihailovic, Mirjana
Journal: Genetics and Molecular Biology
Issue Date: 7-Jun-2011
Abstract: The intention was to evaluate the possible in vivogenotoxic potential in different cell-types, of a methanol extract obtained from the plant stem of Continues coggygriaScop., using the sex-linked recessive lethal (or SLRL) test and alkaline comet assay. The SLRL test, revealed the genotoxic effect of this extract in postmeiotic and premeiotic germ-cell lines. The comet assay was carried out on rat liver and bone marrow at 24 and 72 h after intraperitoneal administration. For genotoxic evaluation, three concentrations of the extract were tested, viz., 500, 1000 and 2000 mg/kg body weight (bw), based on the solubility limit of the extract in saline. Comet tail moment and total scores in the group treated with 500 mg/kg bw, 24 and 72 h after treatment, were not significantly different from the control group, whereas in the groups of animals, under the same conditions, but with 1000 and 2000 mg/kg bw of the extract, scores were statistically so. A slight decrease in the comet score and tail moment observed in all the doses in the 72 h treatment, gave to understand that DNA damage induced by Cotinus coggygria extract decreased with time. The results of both tests revealed the genotoxic effect o f Continue coggygria under our experimental conditions. © 2011, Sociedade Brasileira de Genética. Printed in Brazil.
Type: Article
DOI: 10.1590/S1415-47572011005000001
ISSN: 14154757
SCOPUS: 79957897184
Appears in Collections:Institute for Information Technologies, Kragujevac
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