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Title: Cytotoxicity of gold(III) complexes on A549 human lung carcinoma epithelial cell line
Authors: Arsenijević, Momir
Milovanovic, Marija
Volarevic, Vladislav
Kesić, Ana
Kanjevac, Tatjana
Arsenijevic, Nebojsa
djukic, aleksandar
Bugarčić Z.
Issue Date: 2012
Abstract: We have studied the kinetics of the complex formation of gold(III) complexes, [Au(en)Cl 2] + (dichlorido(ethylendiamine) aurate(III)-ion) [Au(dach)Cl 2] (dichloride(1,2-diaminocyclohexane) aurate(III)-ion) and [Au(bipy)Cl 2] + (dichlorido(2, 2′-bipyridyl)aurate(III)-ion) with guanosine5′-monophosphate (5′-GMP). It was shown that 5′-GMP have a high affinity for gold(III) complex, which may have important biological implications, since the interactions of Au(III) with DNA are thought to be responsible for the anti-tumor activity. The [Au(bipy)Cl 2] + complex is more reactive than [Au(en)Cl 2] + or [Au(dach)Cl 2] +. The activation parameters for all studied reactions suggest an associative substitution mechanism. The cytotoxicity of gold(III) complexes was tested on A549 human lung carcinoma epithelial cell line and was evaluated by cytotoxic (MTT and LDH test) and apoptotic assays. The results showed that all tested gold(III) complexes displayed cytotoxic effect on A549 cells. Among the tested gold (III) complexes, AuBIPY showed the best cytotoxic effects. © 2012 Bentham Science Publishers.
Type: article
DOI: 10.2174/157340612799278469
ISSN: 1573-4064
SCOPUS: 2-s2.0-84858176756
Appears in Collections:Faculty of Medical Sciences, Kragujevac

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