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Title: Patient specific multiscale modelling for plaque formation and progression
Authors: Exarchos T.
Sakellarios, Antonis
Siogkas, Panagiotis
Fotiadis D.
Milosevic Z.
Nikolic, Dalibor
Filipovic, Nenad
Marraccini P.
Vozzi, Federico
Parodi O.
Journal: Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS
Issue Date: 14-Dec-2012
Abstract: We present a three-dimensional model of plaque formation and progression that was tested in a set of patients who underwent coronary Computed Tomography angiography (CTA) for anginal symptoms. The 3D blood flow is described by the Navier-Stokes equations, together with the continuity equation. Mass transfer within the blood lumen and through the arterial wall is coupled with the blood flow and is modeled by a convection-diffusion equation. The Low Density Lipoprotein (LDL) transports in lumen of the vessel and through the vessel tissue (which has a mass consumption term) are coupled by Kedem-Katchalsky equations. The inflammatory process is modeled using three additional reaction-diffusion partial differential equations. A full three-dimensional model was created. Furthermore, features potentially affecting plaque growth, such as patient risk score, circulating biomarkers, localization and composition of the initial plaque, and coronary vasodilating capability were also investigated. The proof of concept of the model effectiveness was assessed 6 months after the baseline evaluation. © 2012 IEEE.
Type: Conference Paper
DOI: 10.1109/EMBC.2012.6346568
ISSN: 1557170X
SCOPUS: 84882995166
Appears in Collections:Faculty of Engineering, Kragujevac
Institute for Information Technologies, Kragujevac
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