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Title: Computational modeling of plaque development in the coronary arteries
Authors: Filipovic, Nenad
Isailovic, Velibor
Milosevic Z.
Nikolic, Dalibor
Saveljic I.
Radović M.
Nikolic, Milica
Cirkovic-Andjelkovic B.
Themis E.
Fotiadis D.
Pelosi, Gualtiero
Parodi O.
Journal: IFMBE Proceedings
Issue Date: 1-Jan-2017
Abstract: © Springer Nature Singapore Pte Ltd. 2017. Computational study for plaque formation and development for the patient specific coronary arteries was performed. Transport of macrophages and oxidized LDL distribution for the initial plaque grow model inside the intimal area was implemented. Mass transport of LDL through the wall and the simplified inflammatory process was firstly solved. The Navier-Stokes equations govern the blood motion in the lumen, the Darcy law is used for model blood filtration, Kedem-Katchalsky equations for the solute and flux exchanges between the lumen and the intima. The system of three additional reaction-diffusion equations that models the inflammatory process and lesion growth model in the intima was used. Some examples of computer simulation for plaque formation and progression for the specific patient for left and right coronary arteries are presented. Determination of plaque location and plaque volume with computer simulation for a specific patient shows a potential benefit for prediction of disease progression.
Type: Conference Paper
DOI: 10.1007/978-981-10-4166-2_40
ISSN: 16800737
SCOPUS: 85016034274
Appears in Collections:Faculty of Engineering, Kragujevac
Institute for Information Technologies, Kragujevac
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