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Title: In vitro and in silico lipoxygenase inhibition studies and antimicrobial activity of pyrazolyl-phthalazine-diones
Authors: Milovanović, Vesna
Petrović, Zorica
Petrović, Vladimir
Simijonović, Dušica
Mladenović, Milan
Tomaševic, Nevena
Čomić, Ljiljana
Radojevic, Ivana
Issue Date: 2021
Abstract: The series of pyrazolyl-phthalazine-dione derivatives (PPDs) was subjected to evaluation of their in vitro lipoxygenase (LOX) inhibition and antimicrobial activities. Results obtained for LOX inhibition activities of PPDs showed that all compounds exhibit good to excellent activity, whereby compounds with eudesmic, syringic, vanillic or toluic moiety are the most active. Molecular modelling study was performed to investigate the possible mechanism of action and binding mode of compounds within the LOX active site. Docking results revealed that activity of the examined compounds depends on the functional group ability to create hydrogen bond accepting (HBA) and hydrophobic features (Hy) in the LOX-Ib active site. In addition, all substances were tested for their antibacterial and antifungal activities. The investigated compounds showed better antifungal than antibacterial activity. The highest antifungal activity was on Aspergillus fumigatus ATTC 204305 and Trichoderma viridae ATCC 13233.
Type: article
DOI: 10.5937/KgJSci2143035M
ISSN: 1450-9636
Appears in Collections:Faculty of Science, Kragujevac
Institute for Information Technologies, Kragujevac

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