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Title: Virtual ABI: A computationally derived ABI index for noninvasive assessment of femoro-popliteal bypass surgery outcome
Authors: Milašinović, Danko
Sekulic, Dejan
Nikolic, Dalibor
Vukicevic, Arso
Tomic Lucic, Aleksandra
Miladinovic, Uroš
Paunovic, Dragana
Filipovic, Nenad
Issue Date: 2021
Abstract: Background and objective: Peripheral arterial disease of the lower limbs, which affects 12-14% of the population, is often treated by bypassing a blocked portion of the vessel. Due to the limited ability of clinicians to predict the outcome of a selected bypass strategy, the five-year graft occlusion ranges from 50% to 90%, with a 20% risk of amputation in the first 5 years after the surgery. The aim of this study was to develop a computational procedure that could enable surgeons to reduce negative effects by assessing patient-specific response to the available surgical strategies. Methods: The Virtual ABI assumes patient-specific finite element modeling of patients’ hemodynamics from routinely acquired medical scans of lower limbs. The key contribution of this study is a novel approach for prescribing boundary conditions, which combines noninvasive preoperative measurements and results of numerical simulations. Results: The validation performed on six follow-up cases indicated high reliability of the Virtual ABI, since the correlation with the experimentally measured values of ankle-brachial index was R² = 0.9485. Conclusion: The initial validation showed that the proposed Virtual ABI is a noninvasive procedure that could assist clinicians to find an optimal strategy for treating a particular patient by varying bypass length, choosing adequate diameter, position and shape.
Type: article
DOI: 10.1016/j.cmpb.2021.106242
ISSN: 0169-2607
SCOPUS: 2-s2.0-85108422716
Appears in Collections:Faculty of Engineering, Kragujevac
Faculty of Hotel Management and Tourism, Vrnjačka Banja
Institute for Information Technologies, Kragujevac

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