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Title: Synthesis and Biological Screening of New 4-Hydroxycoumarin Derivatives and Their Palladium(II) Complexes
Authors: Avdović, Edina
Petrović, Isidora
Stevanovic, Milena
saso, luciano
Dimitrić Marković, Jasmina
Filipovic, Nenad
Zižić, Milan
Cvetic Antic, Tijana
Crnjac Zizic, Marina
Todorovic, Natasa
Vukić, Milena
Trifunović, Srećko
Marković, Zoran
Issue Date: 2021
Abstract: Two newly synthesized 4-hydroxycoumarin bidentate ligands (L1 and L2) and their palladium(II) complexes (C1 and C2) were screened for their biological activities, in vitro and in vivo. Structures of new compounds were established based on elemental analysis, 1H NMR, 13C NMR, and IR spectroscopic techniques. The obtained compounds were tested for their antioxidative and cytotoxic activities and results pointed to selective antiradical activity of palladium(II) complexes towards •OH and -•OOH radicals and anti-ABTS (2,2′-Azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) cation radical) activity comparable to that of ascorbate. Results indicated the effect of C1 and C2 on the enzymatic activity of the antioxidative defense system. In vitro cytotoxicity assay performed on different carcinoma cell lines (HCT166, A375, and MIA PaCa-2), and one healthy fibroblast cell line (MRC-5) showed a cytotoxic effect of both C1 and C2, expressed as a decrease in carcinoma cells' viability, mostly by induction of apoptosis. In vivo toxicity tests performed on zebrafish embryos indicated different effects of C1 and C2, ranging from adverse developmental effect to no toxicity, depending on tested concentration. According to docking studies, both complexes (C1 and C2) showed better inhibitory activity in comparison to other palladium(II) complexes.
Type: article
DOI: 10.1155/2021/8849568
ISSN: 1942-0900
SCOPUS: 2-s2.0-85105724813
Appears in Collections:Faculty of Engineering, Kragujevac
Faculty of Science, Kragujevac
Institute for Information Technologies, Kragujevac

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