Please use this identifier to cite or link to this item: https://scidar.kg.ac.rs/handle/123456789/15946
Title: Orally administered fluorescent nanosized polystyrene particles affect cell viability, hormonal and inflammatory profile, and behavior in treated mice
Authors: Nikolić A.
Gazdic Jankovic M.
Rosic, Gvozden
Miletic Kovacevic, Marina
Jovicic, Nemanja
Nestorović, Nataša
Stojkovic P.
Filipovic, Nenad
Milošević-Đorđević, Olivera
Selakovic, Dragica
Živanović, Marko
Šeklić, Dragana
Milivojević, Nevena
Markovic, Aleksandra
Seist R.
Vasilijic, Sasa
Stankovic K.
Stojković M.
Ljujic, Biljana
Issue Date: 2022
Abstract: Commercially manufactured or generated through environmental degradation, microplastics (MPs) and nanoplastics (NPs) considerably contribute to environmental pollution. There is a knowledge gap in how exposure to MPs/NPs changes cellular function and affects animal and human health. Here, we demonstrate that after oral uptake, fluorescent polystyrene (PS) nanoparticles pass through the mouse digestive system, accumulate and aggregate in different organs, and induce functional changes in cells and organs. Using cochlear explant as a novel in vitro system, we confirmed the consequences of PS-MP/NP interaction with inner ear cells by detecting aggregates and hetero-aggregates of PS particles in hair cells. The testes of treated males accumulated MPs/NPs in the interstitial compartment surrounding the seminiferous tubules, which was associated with a statistically significant decrease in testosterone levels. Male mice showed increased secretion of interleukins (IL-12p35 and IL-23) by splenocytes while cyto- and genotoxicity tests indicated impaired cell viability and increased DNA damage in spleen tissue. Males also showed a broad range of anxiogenic responses to PS nanoparticles while hippocampal samples from treated females showed an increased expression of Bax and Nlrp3 genes, indicating a pro-apoptotic/proinflammatory effect of PS treatment. Taken together, induced PS effects are also gender-dependent, and therefore, strongly motivate future research to mitigate the deleterious effects of nanosized plastic particles.
URI: https://scidar.kg.ac.rs/handle/123456789/15946
Type: article
DOI: 10.1016/j.envpol.2022.119206
ISSN: 0269-7491
SCOPUS: 2-s2.0-85127808162
Appears in Collections:Faculty of Engineering, Kragujevac
Faculty of Medical Sciences, Kragujevac
Faculty of Science, Kragujevac
Institute for Information Technologies, Kragujevac

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