New dinuclear Au(III) complex: Synthesis, characterization and study of the interections with DNA

Abstract

Considering that gold(III) complexes are isostructural and isoelectronic with platinum(II) complexes, the synthesis, characterization and study of their biological activity were very common in the last few years. We have synthesized new dinuclear gold(III) complex with 1.5-naphtiridine as bridging ligand. The structure of this complex was confirmed by different analytical methods (IR, UV-Vis,1H NMR, mass analysis, conductometry). The study of the interactions between complex and DNA was performed by UV-Vis spectrofotometry, fluorescence spectroscopy and viscosity measurement. Based on the results of UV-Vis spectrofotometry can be concluded that complex binds to DNA. According to the results obtained by fluorescence spectroscopy and by viscosity measurement, the covalent binding mode between complex and DNA was confirmed.