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Enhancing Thrombolysis Safety in Post-Acute Ischemic Stroke with Tissue Plasminogen Activator-Associated Microparticles
Recombinant tissue-type plasminogen activator (tPA) is the only approved thrombolytic drug for acute ischemic stroke, a condition associated with severe disabilities and high mortality. However, when the blood-brain barrier (BBB) is damaged, tPA can exacerbate cerebral injury and increase the risk of hemorrhagic transformation, limiting its use to a small subset of patients. To address this challenge and minimize extravascular accumulation, we combined tPA with micrometer-sized particles (DPN...
Recombinant tissue-type plasminogen activator (tPA) is the only approved thrombolytic drug for acute ischemic stroke, a condition associated with severe disabilities and high mortality. However, when the blood-brain barrier (BBB) is damaged, tPA can exacerbate cerebral injury and increase the risk of hemorrhagic transformation, limiting its use to a small subset of patients. To address this challenge and minimize extravascular accumulation, we combined tPA with micrometer-sized particles (DPN...
Cities in energy transition: Local responses to national challenges
Given that cities are major consumers of energy and significant sources of carbon dioxide emissions, this research aims to explore pathways for their decarbonization. At the same time, recognizing that cities are not isolated energy islands but integral parts of national energy systems, the study investigates how the Energy Sector Development Strategy of the Republic of Serbia up to 2040 with Projections up to 2050 can be effectively scaled and adapted to the local context, using the city of ...
Given that cities are major consumers of energy and significant sources of carbon dioxide emissions, this research aims to explore pathways for their decarbonization. At the same time, recognizing that cities are not isolated energy islands but integral parts of national energy systems, the study investigates how the Energy Sector Development Strategy of the Republic of Serbia up to 2040 with Projections up to 2050 can be effectively scaled and adapted to the local context, using the city of ...
An Objective Multi-Attribute Decision-Making Framework for Identifying Critical Phases in Automotive Component Manufacturing
Efficient management of production processes in modern manufacturing depends on the timely identification of their most critical phases, as such recognition directly enhances process reliability, productivity, and product quality. To address this need, an objective multi-attribute decision-making (MADM) framework has been developed by integrating the Criteria Importance Through Inter-criteria Correlation (CRITIC) method with Pareto analysis, a well-established approach also referred to as ABC...
Efficient management of production processes in modern manufacturing depends on the timely identification of their most critical phases, as such recognition directly enhances process reliability, productivity, and product quality. To address this need, an objective multi-attribute decision-making (MADM) framework has been developed by integrating the Criteria Importance Through Inter-criteria Correlation (CRITIC) method with Pareto analysis, a well-established approach also referred to as ABC...
Formulation of Alginate–Gelatin Hydrogels within a Circular Economy Framework: Controlled Release of Grape Skin Extract via Gelatin Content Modulation
Hydrogels, as cross-linked polymer networks, are increasingly utilized in biomedical applications due to their high water absorption, biocompatibility, and capability to deliver bioactive substances. Compared to synthetic hydrogels, natural polymers such as alginate and gelatin provide advantages including biodegradability, low toxicity, and the formation of stable matrices suitable for biomedical use. Grape skins from the Šumadija region in Serbia, a byproduct of winemaking, are abundant in ...
Hydrogels, as cross-linked polymer networks, are increasingly utilized in biomedical applications due to their high water absorption, biocompatibility, and capability to deliver bioactive substances. Compared to synthetic hydrogels, natural polymers such as alginate and gelatin provide advantages including biodegradability, low toxicity, and the formation of stable matrices suitable for biomedical use. Grape skins from the Šumadija region in Serbia, a byproduct of winemaking, are abundant in ...
Grape Skin Extract Hydrogel Restores Systemic Redox Balance in Diabetic Rats
Chronic diabetic wounds are difficult to heal due to prolonged inflammation and oxidative stress, often leading to severe complications. This study aimed to evaluate the systemic redox status in diabetic rats treated with grape skin extract (GSE)-loaded alginate-gelatin hydrogels. Hydrogels were prepared with 8 mg/mL GSE and applied topically to full-thickness skin wounds in streptozotocin-induced diabetic Wistar rats. Redox biomarkers including TBARS, H₂O₂, O₂⁻, SOD, CAT and GSH were analyze...
Chronic diabetic wounds are difficult to heal due to prolonged inflammation and oxidative stress, often leading to severe complications. This study aimed to evaluate the systemic redox status in diabetic rats treated with grape skin extract (GSE)-loaded alginate-gelatin hydrogels. Hydrogels were prepared with 8 mg/mL GSE and applied topically to full-thickness skin wounds in streptozotocin-induced diabetic Wistar rats. Redox biomarkers including TBARS, H₂O₂, O₂⁻, SOD, CAT and GSH were analyze...
Grape Skin Extract–Enriched Hydrogels for Wound Healing: An Antioxidant- Based Approach
Gelatin–alginate hydrogels incorporating grape skin extract (GSE) from the Šumadija region were prepared by blending alginate and gelatin (3:1, 3:2, 1:1), casting, freezing, and CaCl₂ cross-linking. Organoleptic properties, total phenolic content (TPC, Folin–Ciocalteu), and antioxidant activity (DPPH and ABTS microplate assays with Trolox) were evaluated. GSE-loaded hydrogels formed uniform, solid gels. Compared with blank matrices, GSE increased TPC by approximately 46–79% and produced modes...
Gelatin–alginate hydrogels incorporating grape skin extract (GSE) from the Šumadija region were prepared by blending alginate and gelatin (3:1, 3:2, 1:1), casting, freezing, and CaCl₂ cross-linking. Organoleptic properties, total phenolic content (TPC, Folin–Ciocalteu), and antioxidant activity (DPPH and ABTS microplate assays with Trolox) were evaluated. GSE-loaded hydrogels formed uniform, solid gels. Compared with blank matrices, GSE increased TPC by approximately 46–79% and produced modes...
Data mining from oscillatory reactions perturbed by Usnic acid
The influence of Usnic acid was investigated in two iodate based oscillatory reactions: Bray Liebhafsky and Briggs-Raucher with the aim of possible application in determining the reactivity of this acid in complex reaction systems. Obtained results show that Usnic acid added in similar concentration has different influence on these two oscillatory systems.
The influence of Usnic acid was investigated in two iodate based oscillatory reactions: Bray Liebhafsky and Briggs-Raucher with the aim of possible application in determining the reactivity of this acid in complex reaction systems. Obtained results show that Usnic acid added in similar concentration has different influence on these two oscillatory systems.
INSTITUCIONALNI KVALITET I EKONOMSKI RAST U EVROPSKOJ UNIJI I ZEMLJAMA ZAPADNOG BALKANA
Institutional quality represents a key factor of economic growth and European integration. This study empirically analyzes the impact of institutional quality on economic growth in the European Union (EU) member states and Western Balkan countries in the period 1996–2023, using data from the Worldwide Governance Indicators (WGI) database of the World Bank. The analysis encompasses 27 EU member states, including those that joined during the enlargement in 2004, 2007, and 2013, as well as the U...
Institutional quality represents a key factor of economic growth and European integration. This study empirically analyzes the impact of institutional quality on economic growth in the European Union (EU) member states and Western Balkan countries in the period 1996–2023, using data from the Worldwide Governance Indicators (WGI) database of the World Bank. The analysis encompasses 27 EU member states, including those that joined during the enlargement in 2004, 2007, and 2013, as well as the U...
A COMPARATIVE STUDY ON THE TRIBOLOGICAL BEHAVIOR OF NEW AND USED 10W-40 ENGINE OIL APPLIED IN GASOLINE AND DIESEL ENGINES
This study presents a comparative analysis of the tribological behaviour of new and used SAE 10W-40 engine oil, collected from gasoline and diesel passenger car engines and tested under cold-start conditions. The investigation examined the influence of oil aging and engine type on viscosity, friction, and wear. Block-on-disc experiments were performed using aluminium (EN AW-6060) against hardened steel (EN 25CrMo4) following ASTM G77 procedures. The results showed that used oils exhibited low...
This study presents a comparative analysis of the tribological behaviour of new and used SAE 10W-40 engine oil, collected from gasoline and diesel passenger car engines and tested under cold-start conditions. The investigation examined the influence of oil aging and engine type on viscosity, friction, and wear. Block-on-disc experiments were performed using aluminium (EN AW-6060) against hardened steel (EN 25CrMo4) following ASTM G77 procedures. The results showed that used oils exhibited low...
NUMERICAL SIMULATION OF AORTIC DISSECTION: EVALUATING VIRTUAL SURGICAL INTERVENTIONS FOR IMPROVED HEMODYNAMIC OUTCOMES AND PERSONALIZED TREATMENT PLANNING
Aortic dissection is a severe clinical condition that demands a thorough understanding of the interactions between the true and false lumens. In this study, numerical simulations were performed for two patients, generating two preoperative and two postoperative models. The analyses were carried out using the PAKSF solver, a specialized tool for fluid–structure interaction problems. The objective was to evaluate the influence of virtual surgical interventions by examining essential hemody...
Aortic dissection is a severe clinical condition that demands a thorough understanding of the interactions between the true and false lumens. In this study, numerical simulations were performed for two patients, generating two preoperative and two postoperative models. The analyses were carried out using the PAKSF solver, a specialized tool for fluid–structure interaction problems. The objective was to evaluate the influence of virtual surgical interventions by examining essential hemody...
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