Please use this identifier to cite or link to this item: https://scidar.kg.ac.rs/handle/123456789/22394
Title: Development of Anticancer Silver-Incorporated PVDF Nanofibrous Scaffold
Authors: Milenković, Strahinja
Virijevic, Katarina
Grujovic, Nenad
Zivic, Fatima
Issue Date: 2024
Abstract: In this study, we present the fabrication of electrospun scaffolds consisting of polyvinylidene fluoride (PVDF) incorporated with silver nanoparticles (AgNPs) and investigate their potential anticancer properties. Using the electrospinning technique utilizing in-house built electrospinning device, we successfully produced nanofibrous scaffolds incorporating AgNPs through a simple and cost-effective method. Dissolution of 21% of PVDF was achieved in a combination of organic solvents acetone and dimethylformamide (Ac:DMF, volume ratio 1:3). Anticancer efficacy was evaluated through in vitro cytotoxicity assay using MDA-MB-231 breast carcinoma and healthy MRC-5 fibroblast cell lines, yielding promising results that highlight the potential of silver-incorporated PVDF scaffolds for anticancer applications in tissue engineering. Different concentrations of silver nitrate (AgNO3) (0.1%, 0.3%, and 0.5%) were incorporated into the PVDF nanofibrous scaffolds and evaluated by the MTT assay. Notably, the most significant anticancer effect on MDA-MB-231 cancer cells was observed at a concentration of 0.1%, without causing cytotoxic effects on MRC-5 cells, while 0.5% exhibited cytotoxic effects on both cell lines. The data suggest that even slightly higher concentrations of AgNPs can affect the viability of both cell lines. Thus, careful selection of silver nitrate concentration promises to achieve prominent results in in vitro and in vivo biological activities. Future research will focus on further exploring these findings.
URI: https://scidar.kg.ac.rs/handle/123456789/22394
Type: conferenceObject
Appears in Collections:Faculty of Engineering, Kragujevac
Institute for Information Technologies, Kragujevac

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