Please use this identifier to cite or link to this item: https://scidar.kg.ac.rs/handle/123456789/22485
Title: Synthesis of a Pt(II) complex with 2-(phenylselanylmethyl)oxolane as a ligand
Authors: Radenkovic, Ninko
Divac, Vera
Kostic, Marina
Bugarcic, Zorica
Issue Date: 2014
Abstract: Transition metal complexes with organoselenium compounds as ligands have attracted considerable interest due to their biological and biomedical applications. They can display cytotoxic, antimalarian, antileukemic and antitumor properties.1 In our previous work we have screened 2-(phenylselanylmethyl)oxolane (L) for its antioxidant and antiproliferative effect on colon cancer cell line HCT-116 and breast cancer cell line MDA-MB-231. 2 Coordinating L to Pd(II) gave complex which exhibits cytostatic and cytotoxic abilities. To continue this line of work, we have synthetized its Pt(II) analogue, in order to compare its biological activities with those of Pd(II) complex. Herein we report synthesis of a new Pt(II) complex bearing organo-selenium moiety. Ligand L was created using a described method. 3 Compound L was then treated with an excess of K2PtCl4 at 40 C, in EtOH/MeOH mixture as solvent system, and afforded complex C (Scheme 1).
URI: https://scidar.kg.ac.rs/handle/123456789/22485
Type: conferenceObject
Appears in Collections:Institute for Information Technologies, Kragujevac

Downloads(s)

2

Files in This Item:
File Description SizeFormat 
3.40..pdf1.75 MBAdobe PDFView/Open


This item is licensed under a Creative Commons License Creative Commons