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https://scidar.kg.ac.rs/handle/123456789/22486
Title: | Biological evaluation of the 3,4-dihydro-2(1H)-quinoxalinones and 3,4-dihydro-1,4-benzoxazin-2-ones |
Authors: | Petronijević, Jelena ![]() ![]() Joksimović N. ![]() ![]() Kostic, Marina ![]() ![]() Divac, Vera ![]() ![]() Janković, Nenad ![]() ![]() |
Issue Date: | 2018 |
Abstract: | In order to investigate new potential therapeutically active agents, we investigated the biological properties of two small libraries of quinoxalinones and 3,4-dihydro-2(1H)-quinoxalinones (Fig. 1). The results obtained showed that compounds 5, 9–11 have good cytotoxic activity against HeLa cells where the lowest IC50 ǀalue ;ϭϬ.ϰϲ ± Ϭ.ϴϮ μM/ŵLͿ ǁas measured for compound 10. Additionally, the most active compounds (5, 9–11) showed much better selectivity for MRC-5 cells (up to 17.4) compared to cisplatin. In vitro evaluation of the iŶhiďitioŶ of the eŶzLJŵe α-glucosidase showed that compounds 10 and 11 exert significant iŶhiďitioŶ of the eŶzLJŵe at ϱϮ.ϱϰ ± Ϭ.Ϭϵ aŶd ϰϬ.Ϭϵ ± Ϭ.ϰϵ μM, ƌespeĐtiǀelLJ. |
URI: | https://scidar.kg.ac.rs/handle/123456789/22486 |
Type: | conferenceObject |
Appears in Collections: | Institute for Information Technologies, Kragujevac |
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