Please use this identifier to cite or link to this item: https://scidar.kg.ac.rs/handle/123456789/9088
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dc.rights.licenseBY-NC-ND-
dc.contributor.authorŠmit, Biljana-
dc.contributor.authorRodic, Marko-
dc.contributor.authorPavlovic, Radoslav-
dc.date.accessioned2020-09-19T17:26:11Z-
dc.date.available2020-09-19T17:26:11Z-
dc.date.issued2016-
dc.identifier.issn0039-7881-
dc.identifier.urihttps://scidar.kg.ac.rs/handle/123456789/9088-
dc.description.abstract© Georg Thieme Verlag Stuttgart · New York-Synthesis 2016. An efficient strategy for a four-step synthesis of angularly fused tricyclic hydantoins as suitable precursors of cis-fused bicyclic α-amino acids is developed by combining a highly diastereoselective Bucherer-Bergs reaction of 2-alkenylcycloalkanones and a regiospecific selenium-induced closure of pyrrolidine ring. This methodology was applied in a five-step synthesis of bicycloproline derivatives in high overall yield. The method could be used for the multigram preparation of free conformationally constrained bicyclic α-amino acids with two points of diversity (size of cycloalkyl ring and substituent at the pyrrolidine ring).-
dc.rightsopenAccess-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/-
dc.sourceSynthesis (Germany)-
dc.titleSynthesis of Angularly Fused (Homo)triquinane-Type Hydantoins as Precursors of Bicyclic Prolines-
dc.typearticle-
dc.identifier.doi10.1055/s-0035-1561285-
dc.identifier.scopus2-s2.0-84955188563-
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