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Title: Computational analysis of lung deformation after murine pneumonectomy
Authors: Filipovic, Nenad
Gibney B.
Nikolic, Dalibor
Konerding M.
Mentzer S.
Issue Date: 2014
Abstract: In many mammalian species, the removal of one lung (pneumonectomy) is associated with the compensatory growth of the remaining lung. To investigate the hypothesis that parenchymal deformation may trigger lung regeneration, we used microCT scanning to create 3D finite element geometric models of the murine lung pre- and post-pneumonectomy (24 h). The structural correspondence between models was established using anatomic landmarks and an iterative computational algorithm. When compared with the pre-pneumonectomy lung, the post-pneumonectomy models demonstrated significant translation and rotation of the cardiac lobe into the post-pneumonectomy pleural space. 2D maps of lung deformation demonstrated significant heterogeneity; the areas of greatest deformation were present in the subpleural regions of the lobe. Consistent with the previously identified growth patterns, subpleural regions of enhanced deformation are compatible with a mechanical signal - likely involving parenchymal stretch - triggering lung growth. © 2012 © 2012 Taylor & Francis.
Type: article
DOI: 10.1080/10255842.2012.719606
ISSN: 1025-5842
SCOPUS: 2-s2.0-84896516372
Appears in Collections:Faculty of Engineering, Kragujevac
Institute for Information Technologies, Kragujevac

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