Please use this identifier to cite or link to this item: https://scidar.kg.ac.rs/handle/123456789/9676
Title: Intravascular pillars and pruning in the extraembryonic vessels of chick embryos
Authors: Lee G.
Filipovic, Nenad
Lin M.
Gibney B.
Simpson D.
Konerding M.
TSUDA A.
Mentzer S.
Journal: Developmental Dynamics
Issue Date: 1-Jun-2011
Abstract: To investigate the local mechanical forces associated with intravascular pillars and vessel pruning, we studied the conducting vessels in the extraembryonic circulation of the chick embryo. During the development days 13-17, intravascular pillars and blood flow parameters were identified using fluorescent vascular tracers and digital time-series video reconstructions. The geometry of selected vessels was confirmed by corrosion casting and scanning electron microscopy. Computational simulations of pruning vessels suggested that serial pillars form along pre-existing velocity streamlines; blood pressure demonstrated no obvious spatial relationship with the intravascular pillars. Modeling a Reynolds number of 0.03 produced 4 pillars at approximately 20-μm intervals matching the observed periodicity. In contrast, a Reynolds number of 0.06 produced only 2 pillars at approximately 63-μm intervals. Our modeling data indicated that the combination of wall shear stress and gradient of shear predicted the location, direction, and periodicity of developing pillars. © 2011 Wiley-Liss, Inc.
URI: https://scidar.kg.ac.rs/handle/123456789/9676
Type: journal article
DOI: 10.1002/dvdy.22618
ISSN: 10588388
SCOPUS: 79955731137
Appears in Collections:Faculty of Engineering, Kragujevac

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