Please use this identifier to cite or link to this item:
Title: Intravascular pillars and pruning in the extraembryonic vessels of chick embryos
Authors: Lee G.
Filipovic, Nenad
Lin M.
Gibney B.
Simpson D.
Konerding M.
Mentzer S.
Issue Date: 2011
Abstract: To investigate the local mechanical forces associated with intravascular pillars and vessel pruning, we studied the conducting vessels in the extraembryonic circulation of the chick embryo. During the development days 13-17, intravascular pillars and blood flow parameters were identified using fluorescent vascular tracers and digital time-series video reconstructions. The geometry of selected vessels was confirmed by corrosion casting and scanning electron microscopy. Computational simulations of pruning vessels suggested that serial pillars form along pre-existing velocity streamlines; blood pressure demonstrated no obvious spatial relationship with the intravascular pillars. Modeling a Reynolds number of 0.03 produced 4 pillars at approximately 20-μm intervals matching the observed periodicity. In contrast, a Reynolds number of 0.06 produced only 2 pillars at approximately 63-μm intervals. Our modeling data indicated that the combination of wall shear stress and gradient of shear predicted the location, direction, and periodicity of developing pillars. © 2011 Wiley-Liss, Inc.
Type: article
DOI: 10.1002/dvdy.22618
ISSN: 1058-8388
SCOPUS: 2-s2.0-79955731137
Appears in Collections:Faculty of Engineering, Kragujevac

Page views(s)




Files in This Item:
File Description SizeFormat 
10.1002-dvdy.22618.pdf1.77 MBAdobe PDFThumbnail

This item is licensed under a Creative Commons License Creative Commons