Please use this identifier to cite or link to this item: https://scidar.kg.ac.rs/handle/123456789/12511
Title: Mapping cyclic stretch in the postpneumonectomy murine lung
Authors: Filipovic, Nenad
Gibney B.
Kojić M.
Nikolic, Dalibor
Isailovic, Velibor
Ysasi, Alexandra
Konerding M.
Mentzer S.
TSUDA A.
Journal: Journal of Applied Physiology
Issue Date: 1-Nov-2013
Abstract: In many mammalian species, the removal of one lung [pneumonectomy (PNX)] is associated with the compensatory growth of the remaining lung. To investigate the hypothesis that parenchymal deformation may trigger lung regeneration, we used respiratorygated micro-computed tomography scanning to create threedimensional finite-element geometric models of the murine cardiac lobe with cyclic breathing. Models were constructed of respiratorygated micro-computed tomography scans pre-PNX and 24 h post- PNX. The computational models demonstrated that the maximum stretch ratio map was patchy and heterogeneous, particularly in subpleural, juxta-diaphragmatic, and cephalad regions of the lobe. In these parenchymal regions, the material line segments at peak inspiration were frequently two- to fourfold greater after PNX; some regions of the post-PNX cardiac lobe demonstrated parenchymal compression at peak inspiration. Similarly, analyses of parenchymal maximum shear strain demonstrated heterogeneous regions of mechanical stress with focal regions demonstrating a threefold increase in shear strain after PNX. Consistent with previously identified growth patterns, these subpleural regions of enhanced stretch and shear strain are compatible with a mechanical signal, likely involving cyclic parenchymal stretch, triggering lung growth. Copyright © 2013 the American Physiological Society.
URI: https://scidar.kg.ac.rs/handle/123456789/12511
Type: article
DOI: 10.1152/japplphysiol.00635.2013
ISSN: 87507587
SCOPUS: 84887060429
Appears in Collections:Faculty of Engineering, Kragujevac
Institute for Information Technologies, Kragujevac

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